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Conserved Hydrophobic Contacts (CHCs) are defined as residue-residue hydrophobic contacts involving only apolar atoms. The CHCs were presumably subjected to similar constraints during the divergent evolution of a family or superfamily of proteins from a common ancestor; therefore they possibly contain most of the determinants necessary to maintain the fold. CHC_FIND is a method for the automatic identification of the CHCs, which assigns a score for each position of a SCR, based on the residue-residue apolar contact area, computed for the correspondent coordinates of the equivalent positions of the multiple sructural alignment.
 
Superimposition of the SCRs found in PLP, fold type I enzymes and representation of sites involved in making conserved hydrophobic contacts (CHCs). Positions involved in CHCs are represented as colored space fill spheres. The backbones of the 23 superposed structures is shown as grey, solid oval ribbon. PLP is displayed as slate sticks.

Enter in the following form fields the sequence and structural alignment.
CHC_FIND accepts as input the output files of a SCR_FIND search. You can download both files containing the sequence and 3D-coordinates of the SCR using SCR_FIND. If this is the first time you're using SCR_FIND, please follow this TUTORIAL. You can test the program also saving these alignment and structural files on your hard disk.

ENTER HERE THE SEQUENCE ALIGNMENT OF THE SCRs
 
ENTER HERE THE STRUCTURAL ALIGNMENT WITH THE 3D COORDINATES OF THE SCRs
 
You can upload no more than 10MB and no more than 25 structures!